ACTH (1-39) is a synthetic form of the endogenous pituitary hormone extensively used in pre-clinical research to investigate melanocortin-2 receptor (MC2R) activation, cAMP-mediated steroidogenesis, adrenal growth dynamics, and HPA axis feedback loops. This research-grade peptide is produced under stringent GMP-compliant conditions and provided as a lyophilized powder to ensure superior purity, stability, and reliability in experimental applications.
Engineered solely for preclinical investigations, each batch of ACTH (1-39) undergoes a comprehensive quality assessment and includes complete documentation, including a Certificate of Analysis (COA), purity data, and structural verification.
Scientific Overview
ACTH (1-39) binds MC2R on adrenocortical cells to stimulate glucocorticoid production via adenylyl cyclase and cAMP pathways in research settings. Preclinical literature has investigated ACTH (1-39) in the following areas of laboratory study:
- Cortisol and corticosterone biosynthesis pathways in adrenal cortex models
- Adrenal growth and zona fasciculata maintenance mechanisms
- Stress-induced steroidogenic enzyme expression in experimental models
- Oligodendroglial progenitor proliferation and differentiation in CNS cell culture models
- HPA axis dynamics and glucocorticoid feedback in pre-clinical study designs
Why Researchers Choose Our ACTH (1-39)
For laboratories requiring dependable ACTH (1-39) research peptide, our manufacturing process prioritizes reproducibility and scientific precision. Every batch is confirmed for:
- Purity ≥99% by HPLC
- Structural identity via mass spectrometry
- Third-party Certificate of Analysis (COA) available per lot
For Research Use Only. Not for human use.
Research-Referenced Mechanistic Observations (Based on existing preclinical and published literature data — not intended as claims of therapeutic use)
- Binding to MC2R and activation of adenylyl cyclase to increase cAMP and initiate steroidogenesis in adrenocortical cell models
- Adrenal growth and steroid production observations in fetal and adult experimental models dependent on an intact hypothalamo-pituitary axis
- Oligodendroglial progenitor cell proliferation and differentiation observations in glial cell culture systems
- Modulation of p53 expression and apoptotic pathway observations in myocardial tissue culture models
- Investigations into glucocorticoid-independent effects on CNS glia in laboratory settings
- Examination of HPA axis regulation and stress response in rodent and ovine pre-clinical models
