AHK-Cu is a synthetic copper-binding tripeptide (sequence: Ala-His-Lys complexed with Cu²⁺) widely examined in laboratory settings for its interactions with dermal papilla cells, follicular keratinocytes, and vascular components of the hair bulb. This copper-peptide complex facilitates research on cell proliferation, growth factor expression, and tissue remodeling pathways relevant to hair cycle dynamics and dermal microcirculation.
Manufactured under GMP-aligned protocols, AHK-Cu arrives as lyophilized powder with full analytical verification, including structural confirmation via mass spectrometry, purity assessment by HPLC, and a complete third-party Certificate of Analysis (CoA) per batch to ensure consistency and traceability in experimental work.
Key Scientific Features
- ≥98% purity confirmed by reverse-phase HPLC and electrospray mass spectrometry.
- Verified sequence: Ala-His-Lys (AHK) with coordinated copper ion (Cu²⁺); molecular formula C₁₂H₂₁N₅O₄Cu (approx.).
- Lyophilized format optimized for stability and aseptic reconstitution in culture or organoid models.
- Batch-specific third-party CoA documenting purity, identity, copper content, and absence of contaminants.
- Produced in GMP-aligned, ISO-compliant facilities.
- Suited to ex vivo hair follicle organ cultures, dermal papilla cell lines, and angiogenic assay systems.
Research-Referenced Attributes (Pre-clinical literature observations; no therapeutic claims)
- In vitro human hair follicle organ culture models demonstrate that AHK-Cu associates with increased hair shaft elongation and prolonged anagen phase duration (PMID: 17703734, https://pubmed.ncbi.nlm.nih.gov/17703734/).
- Pre-clinical dermal papilla cell cultures show enhanced proliferative activity, reduced apoptotic markers, and upregulation of VEGF expression following exposure to copper tripeptide complexes (various models referenced in PMID: 36608734 review on copper in angiogenesis).
- Ex vivo follicle studies link copper-peptide treatment to improved microcirculation support via VEGF pathways, contributing to nutrient delivery and follicular viability (PMID: 10942094 on VEGF in hair cycling).
- Broader investigations indicate copper tripeptides modulate matrix metalloproteinases, collagen synthesis, and tissue remodeling processes in dermal fibroblast and epithelial models (PMID: 29986520).
Why Researchers Choose Nationwide Peptides AHK-Cu
- Matches the copper-complexed AHK sequence referenced in foundational hair follicle organ culture and dermal papilla studies.
- Provides maximum analytical transparency: HPLC ≥98%, MS verification, and downloadable batch CoA.
- Ensures batch-to-batch reproducibility for consistent results in ex vivo follicle elongation and cell proliferation protocols.
- Trusted by laboratories investigating angiogenic signaling, hair cycle regulation, and copper-mediated dermal mechanisms.
- Offered in standard research vial sizes with competitive pricing and bulk options for extended experiments.
For Research Use Only. This product is supplied strictly for in vitro and in vivo laboratory investigations by qualified researchers in controlled experimental settings. Statements regarding this product have not been evaluated by the FDA. It is not intended for human consumption, injection, diagnostic use, therapeutic application, or any non-research purpose.
