DSIP was first isolated from cerebral venous blood of sleep-deprived rabbits in 1977 by the Swiss Schoenenberger-Monnier group. This amphiphilic nonapeptide crosses the blood-brain barrier freely and modulates sleep-wake cycles, reduces ACTH/cortisol responses to stress, and exhibits antioxidant and anticonvulsant properties. Although never brought to market as a pharmaceutical, it remains one of the most studied natural sleep peptides in Russia and Eastern Europe, where it has been used clinically for insomnia, withdrawal syndromes, and pain management. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation, ideal for sleep, stress, and neuroendocrine research.
Key Scientific Features
- High-purity DSIP (≥ 98% by HPLC/MS, acetate salt form)
- Verified nonapeptide sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, and amino acid analysis
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for sleep induction, ACTH/cortisol suppression, and neuroprotection studies
Research-Referenced Attributes (Based on scientific literature; not intended as therapeutic claims.)
- Promotes delta-wave (slow-wave) sleep and normalizes sleep architecture in insomnia models
- Reduces stress-induced ACTH and cortisol release; used in opioid/alcohol withdrawal studies
- Exhibits analgesic, anticonvulsant, and antioxidant effects in rodent models
- Modulates LH release and may influence dopamine/serotonin systems
- Crosses BBB easily; active via intravenous, subcutaneous, intranasal, and oral routes
- Potential applications in chronic pain, epilepsy, and PTSD-related sleep disturbance research
Why Researchers Choose Nationwide Peptides DSIP
- Exact native sequence match used in original Russian clinical studies
- Highest documented sleep-promoting activity among research suppliers
- Transparent analytical data (HPLC >98%, MS confirmation)
- Trusted by sleep medicine, neuroendocrinology, and addiction research laboratories
- Competitive research pricing with 2 mg, 5 mg, 10 mg, and bulk options
This product is intended strictly for laboratory research use only. Not for human consumption, injection, therapeutic application, or diagnostic procedures. For use by qualified researchers in controlled experimental settings only.
