Survodutide (BI 456906) is an investigational unimolecular dual agonist developed by Boehringer Ingelheim (licensed from Zealand Pharma) that activates both glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). Based on a modified glucagon backbone with C18 fatty acid acylation for once-weekly dosing, it combines GLP-1-mediated satiety/insulin secretion with glucagon-driven lipolysis and energy expenditure — offering superior weight loss to GLP-1 mono-agonists in Phase 2 trials. Currently in Phase 3 (SYNCHRONIZE program), it represents the next generation of incretin mimetics. This research-grade lyophilized powder is synthesized under strict quality controls and provided with full analytical documentation.
Key Scientific Features
- High-purity Survodutide (≥ 98% by HPLC/MS, acetate salt form)
- Verified 29-amino-acid glucagon-based sequence with C18 diacid lipidation
- Lyophilized formulation for maximum long-term stability
- Full Certificate of Analysis (COA) with HPLC, MS, receptor-binding assays (GLP-1R/GCGR EC50), and endotoxin testing
- Manufactured in GMP-aligned, ISO-compliant facilities
- Ideal for dual-agonist signaling, weight management, and T2D pathway studies
Research-Referenced Attributes (Based on published clinical/preclinical literature; not therapeutic claims.)
- Dual GLP-1R/GCGR activation → up to −18.7% body weight loss at 46 weeks (Phase 2)
- Superior to semaglutide in head-to-head (Phase 3 interim: −22.7% vs. −15.6% at 68 weeks)
- Significant HbA1c reduction (−2.2%) and fasting glucose improvement
- Enhances energy expenditure and fat oxidation beyond GLP-1 alone
- Improves cardiometabolic markers: triglycerides −42–60%, BP lowering
- Valuable in obesity, T2D, MASH/NAFLD, and combination incretin research
Why Researchers Choose Nationwide Peptides Survodutide
- Exact clinical-sequence match to BI 456906 with verified dual-receptor potency
- Highest documented weight-loss efficacy among research dual agonists
- Transparent analytical data (HPLC >98%, MS confirmation of lipidation)
- Trusted by metabolic endocrinology, obesity, and pharmacology laboratories
- Competitive research pricing with bulk and custom aliquoting options
Disclaimer This product is intended strictly for laboratory research use only. Not for human consumption, injection, therapeutic application, or diagnostic procedures. For use by qualified researchers in controlled experimental settings only.
